A small-molecular inhibitor against Proteus mirabilis urease to treat catheter-associated urinary tract infections
Infection and blockage of indwelling urinary catheters is significant owing to its high
incidence rate and severe medical consequences. Bacterial enzymes are employed as …
incidence rate and severe medical consequences. Bacterial enzymes are employed as …
Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity
Catheter‐associated urinary tract infection (CAUTI) is the most common healthcare‐
associated infection; however, current therapeutic strategies remain insufficient for standard …
associated infection; however, current therapeutic strategies remain insufficient for standard …
Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease
BC Hunt, V Brix, J Vath, LB Guterman, SM Taddei… - mBio, 2024 - journals.asm.org
Biofilms play an important role in the development and pathogenesis of catheter-associated
urinary tract infection (CAUTI). Proteus mirabilis and Enterococcus faecalis are common …
urinary tract infection (CAUTI). Proteus mirabilis and Enterococcus faecalis are common …
Lipopolysaccharide structure modulates cationic biocide susceptibility and crystalline biofilm formation in Proteus mirabilis
OE Clarke, H Pelling, V Bennett, T Matsumoto… - Frontiers in …, 2023 - frontiersin.org
Chlorhexidine (CHD) is a cationic biocide used ubiquitously in healthcare settings. Proteus
mirabilis, an important pathogen of the catheterized urinary tract, and isolates of this species …
mirabilis, an important pathogen of the catheterized urinary tract, and isolates of this species …
Infection responsive coatings to reduce biofilm formation and encrustation of urinary catheters
AJ Slate, OE Clarke, M Kerio… - Journal of applied …, 2023 - academic.oup.com
Aims The care of patients undergoing long-term urethral catheterization is frequently
complicated by Proteus mirabilis infection. This organism forms dense, crystalline biofilms …
complicated by Proteus mirabilis infection. This organism forms dense, crystalline biofilms …
Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage
RA Heylen, N Cusick, T White, EJ Owen… - RSC medicinal …, 2024 - pubs.rsc.org
Catheter associated urinary tract infections (CAUTI) caused by urease-positive organisms
can lead to catheter blockage: urease metabolizes urea in urine to ammonia causing an …
can lead to catheter blockage: urease metabolizes urea in urine to ammonia causing an …
In vitro coliform resistance to bioactive compounds in urinary infection, assessed in a lab catheterization model
Bioactive compounds and phenolic compounds are viable alternatives to antibiotics in
recurrent urinary tract infections. This study aimed to use a natural functional product, based …
recurrent urinary tract infections. This study aimed to use a natural functional product, based …
Turbidimetric bioassays: A solution to antimicrobial activity detection in asymptomatic bacteriuria isolates against uropathogenic Escherichia coli
Traditional bacteriocin screening methods often face limitations due to diffusion‐related
challenges in agar matrices, which can prevent the peptides from reaching their target …
challenges in agar matrices, which can prevent the peptides from reaching their target …
Weak organic acid synergy towards the prevention of catheter blockages
J Burns, CP McCoy, NJ Irwin - Journal of Hospital Infection, 2021 - Elsevier
Background Up to 50% of all long-term catheterized individuals experience recurrent
episodes of urinary catheter infections and blockages, leading to urine retention …
episodes of urinary catheter infections and blockages, leading to urine retention …
The molybdate-binding protein ModA is required for Proteus mirabilis-induced UTI
Y Huang, J Chen, Q Jiang, N Huang, X Ding… - Frontiers in …, 2023 - frontiersin.org
Background Proteus mirabilis is one of the pathogens commonly causing urinary tract
infections (UTIs). The molybdate-binding protein ModA encoded by modA binds molybdate …
infections (UTIs). The molybdate-binding protein ModA encoded by modA binds molybdate …