A small-molecular inhibitor against Proteus mirabilis urease to treat catheter-associated urinary tract infections

S Milo, RA Heylen, J Glancy, GT Williams… - Scientific reports, 2021 - nature.com
Infection and blockage of indwelling urinary catheters is significant owing to its high
incidence rate and severe medical consequences. Bacterial enzymes are employed as …

Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity

DS Won, H Lee, Y Park, M Chae… - Advanced …, 2024 - Wiley Online Library
Catheter‐associated urinary tract infection (CAUTI) is the most common healthcare‐
associated infection; however, current therapeutic strategies remain insufficient for standard …

Metabolic interplay between Proteus mirabilis and Enterococcus faecalis facilitates polymicrobial biofilm formation and invasive disease

BC Hunt, V Brix, J Vath, LB Guterman, SM Taddei… - mBio, 2024 - journals.asm.org
Biofilms play an important role in the development and pathogenesis of catheter-associated
urinary tract infection (CAUTI). Proteus mirabilis and Enterococcus faecalis are common …

Lipopolysaccharide structure modulates cationic biocide susceptibility and crystalline biofilm formation in Proteus mirabilis

OE Clarke, H Pelling, V Bennett, T Matsumoto… - Frontiers in …, 2023 - frontiersin.org
Chlorhexidine (CHD) is a cationic biocide used ubiquitously in healthcare settings. Proteus
mirabilis, an important pathogen of the catheterized urinary tract, and isolates of this species …

Infection responsive coatings to reduce biofilm formation and encrustation of urinary catheters

AJ Slate, OE Clarke, M Kerio… - Journal of applied …, 2023 - academic.oup.com
Aims The care of patients undergoing long-term urethral catheterization is frequently
complicated by Proteus mirabilis infection. This organism forms dense, crystalline biofilms …

Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RA Heylen, N Cusick, T White, EJ Owen… - RSC medicinal …, 2024 - pubs.rsc.org
Catheter associated urinary tract infections (CAUTI) caused by urease-positive organisms
can lead to catheter blockage: urease metabolizes urea in urine to ammonia causing an …

In vitro coliform resistance to bioactive compounds in urinary infection, assessed in a lab catheterization model

E Vamanu, LD Dinu, CM Luntraru, A Suciu - Applied Sciences, 2021 - mdpi.com
Bioactive compounds and phenolic compounds are viable alternatives to antibiotics in
recurrent urinary tract infections. This study aimed to use a natural functional product, based …

Turbidimetric bioassays: A solution to antimicrobial activity detection in asymptomatic bacteriuria isolates against uropathogenic Escherichia coli

C Kenneally, CP Murphy, RD Sleator… - …, 2024 - Wiley Online Library
Traditional bacteriocin screening methods often face limitations due to diffusion‐related
challenges in agar matrices, which can prevent the peptides from reaching their target …

Weak organic acid synergy towards the prevention of catheter blockages

J Burns, CP McCoy, NJ Irwin - Journal of Hospital Infection, 2021 - Elsevier
Background Up to 50% of all long-term catheterized individuals experience recurrent
episodes of urinary catheter infections and blockages, leading to urine retention …

The molybdate-binding protein ModA is required for Proteus mirabilis-induced UTI

Y Huang, J Chen, Q Jiang, N Huang, X Ding… - Frontiers in …, 2023 - frontiersin.org
Background Proteus mirabilis is one of the pathogens commonly causing urinary tract
infections (UTIs). The molybdate-binding protein ModA encoded by modA binds molybdate …