Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
COVID-19 pandemic, it has become one of the most therapeutically targeted human …
Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA. 5
Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2
KYA Huang, X Chen, A Mohapatra, HTV Nguyen… - Nature …, 2023 - nature.com
Antibody-mediated immunity plays a crucial role in protection against SARS-CoV-2 infection.
We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited …
We isolated a panel of neutralizing anti-receptor-binding domain (RBD) antibodies elicited …
Viral vector vaccine development and application during the COVID-19 pandemic
S Deng, H Liang, P Chen, Y Li, Z Li, S Fan, K Wu, X Li… - Microorganisms, 2022 - mdpi.com
With the accumulation of mutations in SARS-CoV-2 and the continuous emergence of new
variants, the importance of developing safer and effective vaccines has become more …
variants, the importance of developing safer and effective vaccines has become more …
An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters
S Deng, Y Liu, RCY Tam, P Chen, AJ Zhang… - Nature …, 2023 - nature.com
Current available vaccines for COVID-19 are effective in reducing severe diseases and
deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next …
deaths caused by SARS-CoV-2 infection but less optimal in preventing infection. Next …
[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
Chemical Synthesis Creates Single Glycoforms of the Ectodomain of Herpes Simplex Virus-1 Glycoprotein D
J Zhao, X Liu, J Liu, F Ye, B Wei, M Deng… - Journal of the …, 2023 - ACS Publications
Herpes simplex virus-1 (HSV-1) utilizes multiple viral surface glycoproteins to trigger virus
entry and fusion. Among these glycoproteins, glycoprotein D (gD) functions as a receptor …
entry and fusion. Among these glycoproteins, glycoprotein D (gD) functions as a receptor …