Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in
tumors, but its application toward dissecting mechanisms underlying immune-modulating …

Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …

Successful metastasis requires the co-evolution of stromal and cancer cells. We used stable
isotope labeling of amino acids in cell culture coupled with quantitative, label-free …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Repair following injury involves a range of processes–such as re-epithelialization, scar
formation, angiogenesis, inflammation, and more–that function, often together, to restore …

Ovarian cancer is the most lethal gynecological malignancy. It is usually diagnosed at a late
stage, with a 5-yr survival rate of< 30%. The majority of ovarian cancer cases are diagnosed …

The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors
because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only …

The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …