Indole alkaloid synthesis facilitated by photoredox catalytic radical cascade reactions

XY Liu, Y Qin - Accounts of chemical research, 2019 - ACS Publications
Conspectus The monoterpene indole alkaloids, containing over 3000 known members and
more than 40 structural types, represent one of the largest natural product families that have …

Chemical diversity and bioactivities of monoterpene indole alkaloids (MIAs) from six Apocynaceae genera

AE Mohammed, ZH Abdul-Hameed, MO Alotaibi… - Molecules, 2021 - mdpi.com
By the end of the twentieth century, the interest in natural compounds as probable sources of
drugs has declined and was replaced by other strategies such as molecular target-based …

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)

P Dey, A Kundu, A Kumar, M Gupta, BM Lee… - Recent advances in …, 2020 - Elsevier
Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They
are all secondary compounds and collection of miscellaneous elements and biomolecules …

Fischer indole synthesis applied to the total synthesis of natural products

MM Heravi, S Rohani, V Zadsirjan, N Zahedi - RSC advances, 2017 - pubs.rsc.org
One of the oldest and most useful reactions in organic chemistry is the Fischer indole
synthesis (FIS). It is known to have a wide variety of applications including the synthesis of …

Ruthenium(II)‐Catalyzed C−H Activation of Imidamides and Divergent Couplings with Diazo Compounds: Substrate‐Controlled Synthesis of Indoles and 3H‐Indoles

Y Li, Z Qi, H Wang, X Yang, X Li - … Chemie International Edition, 2016 - Wiley Online Library
Indoles are an important structural motif that is commonly found in biologically active
molecules. In this work, conditions for divergent couplings between imidamides and …

Enantioselective palladium-catalyzed allylic alkylation reactions in the synthesis of Aspidosperma and structurally related monoterpene indole alkaloids

BP Pritchett, BM Stoltz - Natural product reports, 2018 - pubs.rsc.org
Covering: up to the end of 2017 Enantioselective Pd-catalyzed allylic alkylations of prochiral
enolates represent a powerful tool for the construction of all-carbon quaternary …

A Gold‐Catalyzed Domino Cyclization Enabling Rapid Construction of Diverse Polyheterocyclic Frameworks

Y He, Z Li, K Robeyns, L Van Meervelt… - Angewandte Chemie …, 2018 - Wiley Online Library
We report herein an efficient gold (I)‐catalyzed post‐Ugi domino dearomatization/ipso‐
cyclization/Michael sequence that enables access to libraries of diverse (hetero) arene …

Harnessing the chemistry of the indole heterocycle to drive discoveries in biology and medicine

VM Norwood IV, RW Huigens III - ChemBioChem, 2019 - Wiley Online Library
Indole‐containing compounds demonstrate an array of biological activities relevant to
numerous human diseases. The biological activities of diverse indole‐based agents are …

[HTML][HTML] Applications of ultrasound in total synthesis of bioactive natural products: A promising green tool

S Majhi - Ultrasonics Sonochemistry, 2021 - Elsevier
Total synthesis is frequently compared to climbing as it provides a suitable route to reach a
high point from the floor, the complex natural product from simple and commercially …

Asymmetric Total Syntheses of Kopsia Indole Alkaloids

L Leng, X Zhou, Q Liao, F Wang, H Song… - Angewandte …, 2017 - Wiley Online Library
The asymmetric total syntheses of a group of structurally complex Kopsia alkaloids,(−)‐
kopsine,(−)‐isokopsine,(+)‐methyl chanofruticosinate,(−)‐fruticosine, and (−)‐kopsanone …