Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …

INTRODUCTION Nearly all cells in the human body share the same primary genome
sequence consisting of four nucleotide bases. One of the bases, cytosine, is commonly …

New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …

The hypothesis that offspring are affected by parental trauma or stress exposure, first noted
anecdotally, is now supported empirically by data from Holocaust survivor offspring cohorts …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …