Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Growing evidence has demonstrated exercise as an effective way to promote cardiovascular
health and protect against cardiovascular diseases However, the underlying mechanisms of …

Physical exercise can improve brain function and delay neurodegeneration; however, the
initial signal from muscle to brain is unknown. Here we show that the lactate receptor …

Acute and chronic animal models of exercise are commonly used in research. Acute
exercise testing is used, often in combination with genetic, pharmacological, or other …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in
many cardiac pathologies, especially heart failure (HF), myocardial infarction and …

Aim Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the
hippocampal formation and the ventricular‐subventricular zone. Neurogenesis in both …

Background Exercise training protects against heart failure. However, the mechanism
underlying the protective effect of exercise training on angiotensin II (Ang II)-induced cardiac …

Background Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced
during hyperglycemia and has been shown to alter intracellular calcium handling in …

Increasing prevalence of diabetes mellitus worldwide has pushed the complex disease state
to the foreground of biomedical research, especially concerning its multifaceted impacts on …

Background Obesity plays an important role in type 2 diabetes mellitus (T2DM) and
myocardial infarction (MI). Ferroptosis and ferritinophagy are related to metabolic pathways …