C9orf72 hexanucleotide repeat expansions are the most common cause of familial
frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) worldwide. The …

Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Olfactory deficits are present in numerous neurodegenerative disorders and are
accompanied by pathology in related brain regions. In several of these disorders, olfactory …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …

Aim Apathy is a prominent symptom of amyotrophic lateral sclerosis (ALS), but measurement
is confounded by physical disability. Furthermore, it has been traditionally measured as a …

Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem
disorder with considerable extra-motor involvement. The neuropsychological manifestations …

Frontotemporal dementia (FTD) phenotypes have distinctive and well-established cortical
signatures, but their subcortical grey matter profiles are poorly characterised. The …

Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent …