Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …

The blood–retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells
covered with pericytes and glia, but the role of the pericytes in BRB regulation is not fully …

Crosstalk between endothelial cells (ECs) and pericytes or vascular smooth muscle cells
(VSMCs) is essential for the proper functioning of blood vessels. This balance is disrupted in …

Single-cell transcriptomics promise to revolutionize our understanding of the vasculature.
Emerging computational methods applied to high-dimensional single-cell data allow …

Advances in multiplex histology allow surveying millions of cells, dozens of cell types, and
up to thousands of phenotypes within the spatial context of tissue sections. This leads to a …

Microvascular networks in the adventitia of large arteries control access of inflammatory cells
to the inner wall layers (media and intima) and thus protect the immune privilege of the aorta …

Low‐flow vascular malformations are congenital overgrowths composed of abnormal blood
vessels potentially causing pain, bleeding and obstruction of different organs. These …

Blood vessels are conduits distributed throughout the body, supporting tissue growth and
homeostasis by the transport of cells, oxygen and nutrients. Endothelial cells (ECs) form the …