Replication-dependent histones are expressed in a cell cycle regulated manner and supply
the histones necessary to support DNA replication. In mammals, the replication-dependent …

Regulation of gene expression includes the replacement of canonical histones for non-
allelic histone variants, as well as their multiple targeting by postranslational modifications …

Although many recent studies describe the emergence and prevalence of “clonal
hematopoiesis of indeterminate potential” in aged human populations, a systematic analysis …

The discovery of driver mutations is one of the key motivations for cancer genome
sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes …

Introduction Natural hair curvature and colour are genetically determined human traits, that
we intentionally change by applying thermal and chemical treatments to the fibre. Presently …

Background Histone isoforms and their post-translational modifications (PTMs) play an
important role in the control of many chromatin-related processes including transcription and …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Contact allergy induced by certain chemicals is a common health concern, and several
alternative methods have been developed to fulfill the requirements of European legislation …

Proliferation and differentiation are controlled through chromatin remodelling. Therefore,
there is an enormous biological significance and clinical value in understanding how …

Background Chromatin is an extraordinarily complex structure. Much of this complexity
results from the presence of numerous histone post-translational modifications and histone …