Abstract The development of Ribosome Profiling (RiboSeq) has revolutionized functional
genomics. RiboSeq is based on capturing and sequencing of the mRNA fragments enclosed …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

Translation is principally regulated at the initiation stage. The development of the translation
initiation (TI) sequencing (TI-seq) technique has enabled the global mapping of TIs and …

An increasing number of studies involve integrative analysis of gene and protein expression
data, taking advantage of new technologies such as next-generation transcriptome …

It is widely suggested that a eukaryotic mRNA typically contains one translation start site and
encodes a single functional protein product. However, according to current points of view on …

Upstream open reading frames (uORFs) latent in mRNA transcripts are thought to modify
translation of coding sequences by altering ribosome activity. Not all uORFs are thought to …

Small proteins specifically refer to proteins consisting of less than 100 amino acids
translated from small open reading frames (sORFs), which were usually missed in previous …

Each human has approximately 50 to 280 frameshifting indels, yet their implications are
unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84 …

Background: Patients with Crohn's disease have defects in intestinal epithelial permeability
that are inadequately explained by known inflammatory bowel disease (IBD) susceptibility …

Even though the functional role of mRNA molecules is primarily decided by the nucleotide
sequence, several properties are determined by secondary structure conformations …