The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Changes in the intestinal microbiome have been associated with obesity and type 2
diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free …

Patients with type 2 diabetes mellitus (T2DM) are at high risk for macrovascular
complications, which represent the major cause of mortality. Despite effective treatment of …

Obesity is associated with chronic inflammation, which contributes to insulin resistance and
type 2 diabetes mellitus. Under normal conditions, skeletal muscle is responsible for the …

The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

One of the most common chronic liver disorders, affecting mainly people in Western
countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …

Insulin resistance is a major underlying mechanism for the “metabolic syndrome”, which is
also known as insulin resistance syndrome. Metabolic syndrome is increasing at an …