[HTML][HTML] TGF-β signaling in health and disease
J Massagué, D Sheppard - Cell, 2023 - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
Contextual determinants of TGFβ action in development, immunity and cancer
CJ David, J Massagué - Nature reviews Molecular cell biology, 2018 - nature.com
Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
JSL Yu, W Cui - Development, 2016 - journals.biologists.com
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …
mammalian target of rapamycin (mTOR) constitute the core components of the …
Signaling cross talk between TGF-β/Smad and other signaling pathways
K Luo - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
FGF signaling pathway: a key regulator of stem cell pluripotency
M Mossahebi-Mohammadi, M Quan… - Frontiers in cell and …, 2020 - frontiersin.org
Pluripotent stem cells (PSCs) isolated in vitro from embryonic stem cells (ESCs), induced
PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for …
PSC (iPSC) and also post-implantation epiblast-derived stem cells (EpiSCs) are known for …
Protein post-translational modifications and regulation of pluripotency in human stem cells
Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …
Wnt signaling in stem and cancer stem cells
JD Holland, A Klaus, AN Garratt… - Current opinion in cell …, 2013 - Elsevier
The functional versatility of Wnt/β-catenin signaling can be seen by its ability to act in stem
cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis …
cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis …
Beyond TGFβ: roles of other TGFβ superfamily members in cancer
LM Wakefield, CS Hill - Nature Reviews Cancer, 2013 - nature.com
Much of the focus on the transforming growth factor-β (TGFβ) superfamily in cancer has
revolved around the TGFβ ligands themselves. However, it is now becoming apparent that …
revolved around the TGFβ ligands themselves. However, it is now becoming apparent that …
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …
Despite sharing the common property of pluripotency, hESCs are notably distinct from …