The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
[HTML][HTML] Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …
Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
[HTML][HTML] Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals
R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand
to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific …
to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific …
[HTML][HTML] Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
A Promonet, I Padioleau, Y Liu, L Sanz… - Nature …, 2020 - nature.com
R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …
nuclear processes and trigger DNA damage, genome instability, and cell killing. By different …
[HTML][HTML] Senataxin resolves RNA: DNA hybrids forming at DNA double-strand breaks to prevent translocations
Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …