Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …

Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of
primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient …

Obesity symbolizes a major public health problem. Overweight and obesity are associated to
the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose …

All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or
photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor
initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …