Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

Glycans are major constituents of extracellular vesicles (EVs). Alterations in the
glycosylation pathway are a common feature of cancer cells, which gives rise to de novo or …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial
polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role …

Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate
their structure and function. Glycans modify proteins required for regulation of immune cells …

Cisplatin-based chemotherapeutic regimens are the most frequently used (neo) adjuvant
treatments for the majority of solid tumors. While platinum-based chemotherapeutic …