Innate and adaptive immune responses in asthma

ST Holgate - Nature medicine, 2012 - nature.com
The recognition that asthma is primarily an inflammatory disorder of the airways associated
with T helper type 2 (TH2) cell-dependent promotion of IgE production and recruitment of …

Pathogenesis of asthma

ST Holgate - Clinical & Experimental Allergy, 2008 - Wiley Online Library
While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface

A Leonardi, E Bogacka, JL Fauquert, ML Kowalski… - Allergy, 2012 - Wiley Online Library
Ocular allergy includes several clinically different conditions that can be considered as
hypersensitivity disorders of the ocular surface. The classification of these conditions is …

Epithelial barrier dysfunction in ocular allergy

N Singh, Y Diebold, SK Sahu, A Leonardi - Allergy, 2022 - Wiley Online Library
The epithelial barrier is the first line of defense that forms a protective barrier against
pathogens, pollutants, and allergens. Epithelial barrier dysfunction has been recently …

Immunopathogenesis of ocular allergy: a schematic approach to different clinical entities

A Leonardi, C De Dominicis… - Current opinion in allergy …, 2007 - journals.lww.com
A review of the recent literature allows us to better understand the mechanisms involved in
the development of ocular allergy and to guide us toward a more schematic approach, which …

[HTML][HTML] Specific probiotics alleviate allergic rhinitis during the birch pollen season

AC Ouwehand, M Nermes, MC Collado… - World journal of …, 2009 - ncbi.nlm.nih.gov
AIM: To investigate whether birch pollen allergy symptoms are linked with gut microbiota
changes and whether probiotics have an effect on these. METHODS: Forty seven children …

Molecular immunology of allergic conjunctivitis

MT Irkec, B Bozkurt - Current opinion in allergy and clinical …, 2012 - journals.lww.com
Recent findings in molecular immunology of ocular allergy, which comprise complex
inflammatory conditions of the conjunctiva, have enabled us to better understand the …

Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis

SJ Ono, K Lane - Drug Design, Development and Therapy, 2011 - Taylor & Francis
Background Antihistamines constitute the first line of therapy for allergic conjunctivitis, and
are safe and effective in relieving the signs and symptoms of ocular allergy. Despite this …

[HTML][HTML] Abnormal epithelial differentiation and tear film alteration in pinguecula

N Dong, W Li, H Lin, H Wu, C Li, W Chen… - … & visual science, 2009 - arvojournals.org
methods. Twelve patients (12 eyes) who underwent simple excision for pingueculae were
enrolled in the study. Immunostaining for K14, K19, K10, MUC5AC, Pax6, P63, Ki67, and …

Hyaluronan receptors in the human ocular surface: a descriptive and comparative study of RHAMM and CD44 in tissues, cell lines and freshly collected samples

L García-Posadas, L Contreras-Ruiz… - Histochemistry and cell …, 2012 - Springer
The purpose of this study was to demonstrate the presence of the receptor for hyaluronan-
mediated motility (RHAMM) in human conjunctival epithelium and in two widely used cell …