Small-cell lung cancer

CM Rudin, E Brambilla, C Faivre-Finn… - Nature Reviews Disease …, 2021 - nature.com
Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

Extensive-stage small-cell lung cancer: first-line and second-line treatment options

J Zugazagoitia, L Paz-Ares - Journal of Clinical Oncology, 2022 - ascopubs.org
Extensive-stage small-cell lung cancer is a therapeutically challenging disease. After more
than two decades without clinical progress, the addition of programmed cell death protein 1 …

Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

AMC Dingemans, M Früh, A Ardizzoni… - Annals of …, 2021 - annalsofoncology.org
Small-cell lung cancer (SCLC) is the most aggressive form of lung cancer. Although SCLC is
characterised by rapid responses to chemotherapy (ChT) and sensitivity to radiotherapy …

Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial

SJ Antonia, JA López-Martin, J Bendell, PA Ott… - The Lancet …, 2016 - thelancet.com
Background Treatments for small-cell lung cancer (SCLC) after failure of platinum-based
chemotherapy are limited. We assessed safety and activity of nivolumab and nivolumab plus …

[HTML][HTML] Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

A Thomas, N Takahashi, VN Rajapakse, X Zhang… - Cancer Cell, 2021 - cell.com
Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse
primary sites that lack effective treatments. Using chemical genetic screens, we identified …

Efficacy and safety of rovalpituzumab tesirine in third-line and beyond patients with DLL3-expressing, relapsed/refractory small-cell lung cancer: results from the phase …

D Morgensztern, B Besse, L Greillier… - Clinical Cancer …, 2019 - AACR
Purpose: Although extensive-stage small-cell lung cancer (SCLC) is highly responsive to
first-line therapy, virtually all patients develop resistance with short survival. Rovalpituzumab …

[HTML][HTML] Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes

M Offin, JM Chan, M Tenet, HA Rizvi, R Shen… - Journal of Thoracic …, 2019 - Elsevier
Introduction EGFR-mutant lung cancers are clinically and genomically heterogeneous with
concurrent RB transcriptional corepressor 1 (RB1)/tumor protein p53 (TP53) alterations …

Unravelling the biology of SCLC: implications for therapy

JK Sabari, BH Lok, JH Laird, JT Poirier… - Nature reviews Clinical …, 2017 - nature.com
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …

ENETS consensus guidelines for high-grade gastroenteropancreatic neuroendocrine tumors and neuroendocrine carcinomas

R Garcia-Carbonero, H Sorbye, E Baudin… - …, 2016 - karger.com
R. Garcia-Carbonero a H. Sorbye b E. Baudin c E. Raymond d B. Wiedenmann e B. Niederle
f E. Sedlackova g C. Toumpanakis h M. Anlauf i JB Cwikla j M. Caplin k D. O'Toole l A …

Small cell lung cancer: where do we go from here?

LA Byers, CM Rudin - Cancer, 2015 - Wiley Online Library
Small cell lung cancer (SCLC) is an aggressive disease that accounts for approximately
14% of all lung cancers. In the United States, approximately 31,000 patients are diagnosed …