Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

Olea europaea L-derived secoiridoids: Beneficial health effects and potential therapeutic approaches

S Filardo, M Roberto, D Di Risola, L Mosca… - Pharmacology & …, 2024 - Elsevier
Over the years, health challenges have become increasingly complex and global and, at the
beginning of the 21st century, chronic diseases, including cardiovascular, neurological, and …

An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties

R Infante, M Infante, D Pastore, F Pacifici… - International Journal of …, 2023 - mdpi.com
Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has
been shown to exert beneficial effects on human health, such as the prevention of chronic …

Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies

AE Alkhalifa, NF Al-Ghraiybah, A Kaddoumi - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques …

Neuroprotective Effects of Olive Oil: A Comprehensive Review of Antioxidant Properties

M Gonçalves, N Vale, P Silva - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases are a significant challenge to global healthcare, and oxidative
stress plays a crucial role in their development. This paper presents a comprehensive …

[HTML][HTML] Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia

AL White, GM Talkington, B Ouvrier, S Ismael… - Biomolecules, 2024 - mdpi.com
Vascular dementia (VaD) is a progressive neurodegenerative condition prevalent among
elderly adults marked by cognitive decline resulting from injured and/or improperly …

[HTML][HTML] Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving …

P Papadopoulou, A Polissidis, G Kythreoti… - International Journal of …, 2024 - mdpi.com
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic
potential to treat neuroinflammation and cognitive impairment. This review examines the …

Pathophysiological role of high mobility group box-1 signaling in neurodegenerative diseases

V Kumar, P Kumar - Inflammopharmacology, 2024 - Springer
Nucleocytoplasmic translocation of HMGB1 (high mobility group box-1) plays a significant
role in disease progression. Several methods contribute to the translocation of HMGB1 from …

Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer's Disease

E Yang, J Wang, LN Woodie, MW Greene, A Kaddoumi - Molecules, 2023 - mdpi.com
Aging is a major risk factor for Alzheimer's disease (AD). AD mouse models are frequently
used to assess pathology, behavior, and memory in AD research. While the pathological …

A theoretical model of dietary lipid variance as the origin of primary ciliary dysfunction in preeclampsia

NR Hart - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Serving as the cell's key interface in communicating with the outside world, primary cilia
have emerged as an area of multidisciplinary research interest over the last 2 decades …