Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Oxysterols are oxidized derivatives of cholesterol, both endogenous and exogenous. They
have been implicated in numerous pathologies, including cancer. In addition to their roles in …

Tumour cells are characterized by having lost their differentiation state. They constitutively
secrete small extracellular vesicles (sEV) called exosomes when they come from late …

Acanthospermum hispidum DC (Asteraceae), a traditional medicinal plant, plays a role as
an alternative remedy for various diseases, such as bacterial and viral infections, jaundice …

Non-Hodgkin's lymphoma (NHL) is the third most common malignant tumor among children.
However, at initial NHL diagnosis, most cases are at an advanced stage because of …

Epidemiological data have shown a positive correlation between lipid levels and tumor
occurrence, such as the correlation between tumor frequency and aggressiveness, and …

Liver X receptor (LXR) agonists, including synthetic ligands or naturally-occurring oxysterols,
exert promising lipid-modulating, anti-inflammatory, and anti-tumor effects. Matrix-assisted …

Abstract N, N-Dimethyl 3β-hydroxychol-5-en-24-amide (DMHCA, 3) is the prototype of
cholenamides, a class of steroidal LXR modulators characterized by the nucleus of Δ5 …

This review provides the up-to-date physiological, pathophysiological, and carcinogenic
roles of autophagy in the thyroid. The data on its physiological roles are mainly obtained …

胆固醇是细胞膜的重要组成成分, 异常的胆固醇代谢不仅和心血管疾病密切相关,
也和肿瘤的发生, 发展密不可分. 肿瘤细胞在侵袭和转移的过程中, 需要大量的胆固醇来满足自身 …