Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

The development of sensitive chromogenic chemosensors for sensing Cu 2+ has been
receiving much attention in recent years because of their potential application in clinical …

Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

The potent redox activity of copper is required for sustaining life. Mismanagement of its
cellular pools, however, can result in oxidative stress and damage connected to aging …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Many mutations confer one or more toxic function (s) on copper/zinc superoxide dismutase 1
(SOD1) that impair motor neuron viability and cause familial amyotrophic lateral sclerosis …

Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical
to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion …

▪ Abstract Many neurodegenerative diseases, including Alzheimer's and Parkinson's and the
transmissible spongiform encephalopathies (prion diseases), are characterized at autopsy …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder,
characterized mainly by a loss of motor neurons (MNs) in the CNS. Over the past decades …