Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic
nerve (ON) severely affects vision. Understanding the molecular mechanism of …

Abstract Dihydroceramide desaturase 1 (DEGS1) converts dihydroceramide (dhCer) to
ceramide (Cer) by inserting a C4-C5 trans (∆ 4E) double bond into the sphingoid backbone …

Multiple sclerosis (MS) is a complex auto-immune disorder of the central nervous system
(CNS) that involves a range of CNS and immune cells. MS is characterized by chronic …

Peripheral nerve injury (PNI) is encountered relatively commonly in the clinic and often
results in long-term functional deficits. Research to develop methods to improve …

Progranulin (PGRN) and transmembrane protein 106B (TMEM 106B) are important
lysosomal proteins implicated in frontotemporal lobar degeneration (FTLD) and other …

Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

Multiple sclerosis (MS), a white matter demyelinating disease of the central nervous system
(CNS), is characterized by neuroinflammatory and neurodegenerative. Experimental …

Autophagy is a robust cellular mechanism for disposing of harmful molecules or recycling
them to cells, which also regulates physiopathological processes in cornea. Dysregulated …