▪ Abstract Fifteen years ago, we had a model of peroxisome biogenesis that involved growth
and division of preexisting peroxisomes. Today, thanks to genetically tractable model …

Abstract In trypanosomatids (Trypanosoma and Leishmania), protozoa responsible for
serious diseases of mankind in tropical and subtropical countries, core carbohydrate …

The peroxisomal isoform of ascorbate peroxidase (APX) is a novel membrane isoform that
functions in the regeneration of NAD+ and protection against toxic reactive oxygen species …

Targeted mRNA trafficking and local translation may play a significant role in controlling
protein localization. Here we examined for the first time the localization of all (≈ 50) mRNAs …

Peroxisome biogenesis conceptually consists of the (a) formation of the peroxisomal
membrane,(b) import of proteins into the peroxisomal matrix and (c) proliferation of the …

Recent studies in human cells and in the yeast Yarrowia lipolytica have shown that
peroxisomes consist of numerous structurally distinct subcompartments that differ in their …

Peroxisomes are organelles that confine an important set of enzymes within their single
membrane boundaries. In man, a wide variety of genetic disorders is caused by loss of …

Most newly synthesized peroxisomal matrix proteins are targeted to the organelle by Pex5p,
the peroxisomal cycling receptor. According to current models of peroxisomal biogenesis …

Peroxisomes are metabolic organelles with enzymatic content that are found in virtually all
cells and are involved in β‐oxidation of fatty acids, hydrogen peroxide‐based respiration …

Peroxisomes compartmentalize part of the anabolic and catabolic pathways and reactions of
the cell. Dysfunction of a single peroxisomal enzyme or loss of the whole peroxisomal …