Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms
JD Humphrey, GA Holzapfel - Journal of biomechanics, 2012 - Elsevier
Biomechanical factors play fundamental roles in the natural history of abdominal aortic
aneurysms (AAAs) and their responses to treatment. Advances during the past two decades …
aneurysms (AAAs) and their responses to treatment. Advances during the past two decades …
Biomechanical phenotyping of central arteries in health and disease: advantages of and methods for murine models
J Ferruzzi, MR Bersi, JD Humphrey - Annals of biomedical engineering, 2013 - Springer
The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …
A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms
P Di Achille, G Tellides… - Proceedings of the …, 2014 - royalsocietypublishing.org
Intraluminal thrombus (ILT) is present in over 75% of all abdominal aortic aneurysms (AAAs)
and probably contributes to the complex biomechanics and pathobiology of these lesions. A …
and probably contributes to the complex biomechanics and pathobiology of these lesions. A …
Mechanical and structural changes in human thoracic aortas with age
Aortic mechanical and structural characteristics have profound effects on pathophysiology,
but many aspects of physiologic stress-stretch state and intramural changes due to aging …
but many aspects of physiologic stress-stretch state and intramural changes due to aging …
Quantification of regional differences in aortic stiffness in the aging human
There has been a growing awareness over the past decade that stiffening of the aorta, and
its attendant effects on hemodynamics, is both an indicator and initiator of diverse …
its attendant effects on hemodynamics, is both an indicator and initiator of diverse …
Spatial orientation of collagen fibers in the abdominal aortic aneurysm's wall and its relation to wall mechanics
TC Gasser, S Gallinetti, X Xing, C Forsell… - Acta biomaterialia, 2012 - Elsevier
Collagen is the most abundant protein in mammals and provides the abdominal aortic
aneurysm (AAA) wall with mechanical strength, stiffness and toughness. Specifically, the …
aneurysm (AAA) wall with mechanical strength, stiffness and toughness. Specifically, the …
Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome
J Ferruzzi, MJ Collins, AT Yeh… - Cardiovascular …, 2011 - academic.oup.com
Aims Elastin is the primary component of elastic fibres in arteries, which contribute
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …
significantly to the structural integrity of the wall. Fibrillin-1 is a microfibrillar glycoprotein that …
Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the …
Elastic and muscular arteries differ in structure, function, and mechanical properties, and
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …
may adapt differently to aging. We compared the descending thoracic aortas (TA) and the …
Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection
S Roccabianca, GA Ateshian, JD Humphrey - Biomechanics and modeling …, 2014 - Springer
Spontaneous dissection of the human thoracic aorta is responsible for significant morbidity
and mortality, yet this devastating biomechanical failure process remains poorly understood …
and mortality, yet this devastating biomechanical failure process remains poorly understood …
Importance of initial aortic properties on the evolving regional anisotropy, stiffness and wall thickness of human abdominal aortic aneurysms
Complementary advances in medical imaging, vascular biology and biomechanics promise
to enable computational modelling of abdominal aortic aneurysms to play increasingly …
to enable computational modelling of abdominal aortic aneurysms to play increasingly …