The integrated stress response
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
Targeting the integrated stress response in cancer therapy
X Tian, S Zhang, L Zhou, AA Seyhan… - Frontiers in …, 2021 - frontiersin.org
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …
The integrated stress response and phosphorylated eukaryotic initiation factor 2α in neurodegeneration
S Bond, C Lopez-Lloreda, PJ Gannon… - … of Neuropathology & …, 2020 - academic.oup.com
The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …
varied, precluding the development of effective therapies for these increasingly prevalent …
Mitostasis, calcium and free radicals in health, aging and neurodegeneration
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
Inside the β cell: molecular stress response pathways in diabetes pathogenesis
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to
their major molecular insults (loss of immune tolerance and onset of tissue insulin …
their major molecular insults (loss of immune tolerance and onset of tissue insulin …
Ribonucleic acid-mediated control of protein translation under stress
MJ Payea, SA Dar, S Malla… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: The need of cells to constantly respond to endogenous and exogenous stress
has necessitated the evolution of pathways to counter the deleterious effects of stress and to …
has necessitated the evolution of pathways to counter the deleterious effects of stress and to …
Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes
Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …
[HTML][HTML] The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology
H Fanlo-Ucar, P Picón-Pagès, V Herrera-Fernández… - Antioxidants, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the
seventh leading cause of death worldwide. It is characterized by the extracellular …
seventh leading cause of death worldwide. It is characterized by the extracellular …
Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity
B Guivernau, J Bonet, V Valls-Comamala… - Journal of …, 2016 - Soc Neuroscience
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological
aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal …
aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal …