The integrated stress response

K Pakos‐Zebrucka, I Koryga, K Mnich, M Ljujic… - EMBO …, 2016 - embopress.org
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

[HTML][HTML] Functions and dysfunctions of nitric oxide in brain

P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

Targeting the integrated stress response in cancer therapy

X Tian, S Zhang, L Zhou, AA Seyhan… - Frontiers in …, 2021 - frontiersin.org
The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

The integrated stress response and phosphorylated eukaryotic initiation factor 2α in neurodegeneration

S Bond, C Lopez-Lloreda, PJ Gannon… - … of Neuropathology & …, 2020 - academic.oup.com
The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …

Mitostasis, calcium and free radicals in health, aging and neurodegeneration

JA Godoy, JA Rios, P Picón-Pagès… - Biomolecules, 2021 - mdpi.com
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Inside the β cell: molecular stress response pathways in diabetes pathogenesis

A Kulkarni, C Muralidharan, SC May, SA Tersey… - …, 2023 - academic.oup.com
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to
their major molecular insults (loss of immune tolerance and onset of tissue insulin …

Ribonucleic acid-mediated control of protein translation under stress

MJ Payea, SA Dar, S Malla… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: The need of cells to constantly respond to endogenous and exogenous stress
has necessitated the evolution of pathways to counter the deleterious effects of stress and to …

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes

MV Lourenco, ST Ferreira, FG De Felice - Progress in neurobiology, 2015 - Elsevier
Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …

[HTML][HTML] The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology

H Fanlo-Ucar, P Picón-Pagès, V Herrera-Fernández… - Antioxidants, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, and it is currently the
seventh leading cause of death worldwide. It is characterized by the extracellular …

Amyloid-β peptide nitrotyrosination stabilizes oligomers and enhances NMDAR-mediated toxicity

B Guivernau, J Bonet, V Valls-Comamala… - Journal of …, 2016 - Soc Neuroscience
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the pathological
aggregation of the amyloid-β peptide (Aβ). Monomeric soluble Aβ can switch from helicoidal …