Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain
SARS-CoV-2 is a novel coronavirus that infects cells through the angiotensin-converting
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
enzyme 2 receptor, aided by proteases that prime the spike protein of the virus to enhance …
T cell immunity in HSV-1-and VZV-infected neural ganglia
Herpesviruses hijack the MHC class I (MHC I) and class II (MHC II) antigen-presentation
pathways to manipulate immune recognition by T cells. First, we illustrate herpes simplex …
pathways to manipulate immune recognition by T cells. First, we illustrate herpes simplex …
On the feasibility of mining CD8+ T cell receptor patterns underlying immunogenic peptide recognition
Current T cell epitope prediction tools are a valuable resource in designing targeted
immunogenicity experiments. They typically focus on, and are able to, accurately predict …
immunogenicity experiments. They typically focus on, and are able to, accurately predict …
[HTML][HTML] Investigation of susceptibility genes for chickenpox disease across multiple continents
LM Irham, W Adikusuma, L Lolita… - … and Biophysics Reports, 2023 - Elsevier
Chickenpox (varicella) is caused by infection with the varicella-zoster virus (VZV), a
neurotropic alpha herpes virus with a double-stranded DNA genome. Chickenpox can …
neurotropic alpha herpes virus with a double-stranded DNA genome. Chickenpox can …
Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox
B Ogunjimi, J Van den Bergh, P Meysman… - Scientific Reports, 2017 - nature.com
Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly.
This secondary immune response is hypothesized to confer protection against herpes …
This secondary immune response is hypothesized to confer protection against herpes …
The impact of HLA polymorphism on herpesvirus infection and disease
Abstract Human Leukocyte Antigens (HLA) are cell surface molecules, central in
coordinating innate and adaptive immune responses, that are targets of strong diversifying …
coordinating innate and adaptive immune responses, that are targets of strong diversifying …
Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster
Varicella-zoster virus (VZV) causes chickenpox and reactivation of latent VZV causes herpes
zoster (HZ). VZV reactivation is subject to the opposing mechanisms of declining and …
zoster (HZ). VZV reactivation is subject to the opposing mechanisms of declining and …
Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice
Objective: We aimed to test the effect of treatment with KF in pain assays in mice and in a
case series of patients with chronic widespread pain. Methods: The analgesic effect of KF …
case series of patients with chronic widespread pain. Methods: The analgesic effect of KF …
Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation
M Boeren, N de Vrij, MK Ha, S Valkiers, A Souquette… - Cell reports, 2024 - cell.com
The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well
understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) …
understood. We use a systems immunology approach on three cohorts of herpes zoster (HZ) …
Identifying and Evaluating Biological Markers of Postherpetic Neuralgia: A Comprehensive Review
Y Li, J Jin, X Kang, Z Feng - Pain and Therapy, 2024 - Springer
Postherpetic neuralgia (PHN) manifests as persistent chronic pain that emerges after a
herpes zoster outbreak and greatly diminishes quality of life. Unfortunately, its treatment …
herpes zoster outbreak and greatly diminishes quality of life. Unfortunately, its treatment …