Biomedical implants have been widely used in various orthopedic treatments, including total
hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern …

Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

Therapeutic growth factor delivery typically requires supraphysiological dosages, which can
cause undesirable off-target effects. The aim of this study was to 3D bioprint implants …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Fracture healing is a specialized post‐natal repair process that recapitulates aspects of
embryological skeletal development. While many of the molecular mechanisms that control …

Tendon healing is a complex and highly-regulated process that is initiated, sustained and
eventually terminated by a large number and variety of molecules. Growth factors represent …

Fracture healing is a complex physiological process. It involves the coordinated participation
of haematopoietic and immune cells within the bone marrow in conjunction with vascular …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

Once thought to result from passive precipitation of calcium and phosphate, it now appears
that vascular calcification is a consequence of tightly regulated processes that culminate in …