Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Kinase inhibition in autoimmunity and inflammation

AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Mineralocorticoid receptor antagonists in diabetic kidney disease—Mechanistic and therapeutic effects

J Barrera-Chimal, I Lima-Posada, GL Bakris… - Nature Reviews …, 2022 - nature.com
Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and
current therapies that limit CKD progression and the development of cardiovascular disease …

Signaling pathways of chronic kidney diseases, implications for therapeutics

Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

TGF-β: the master regulator of fibrosis

X Meng, DJ Nikolic-Paterson, HY Lan - Nature Reviews Nephrology, 2016 - nature.com
Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

[HTML][HTML] Update of pathophysiology and management of diabetic kidney disease

YC Lin, YH Chang, SY Yang, KD Wu, TS Chu - Journal of the formosan …, 2018 - Elsevier
Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with
diabetes mellitus and the leading cause of end-stage renal disease in the world. The most …

Diabetic nephropathy: update on pillars of therapy slowing progression

SC Naaman, GL Bakris - Diabetes Care, 2023 - Am Diabetes Assoc
Management of diabetic kidney disease (DKD) has evolved in parallel with our growing
understanding of the multiple interrelated pathophysiological mechanisms that involve …

Fibrosis—a common pathway to organ injury and failure

DC Rockey, PD Bell, JA Hill - New England Journal of Medicine, 2015 - Mass Medical Soc
Fibrosis — A Common Pathway to Organ Injury and Failure | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

Signaling pathways involved in diabetic renal fibrosis

Y Zhang, D Jin, X Kang, R Zhou, Y Sun… - Frontiers in cell and …, 2021 - frontiersin.org
Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …