[HTML][HTML] Alzheimer's disease: an updated overview of its genetics
J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …
classified as familial and sporadic. The dominant familial or autosomal presentation …
[HTML][HTML] Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases
RJ Boyd, D Avramopoulos, LL Jantzie… - Journal of …, 2022 - Springer
Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …
onset, and penetrance. These diseases tend to be relatively common and arise from the …
[HTML][HTML] Redox signaling and metabolism in Alzheimer's disease
MI Holubiec, M Gellert… - Frontiers in Aging …, 2022 - frontiersin.org
Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …
[HTML][HTML] Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease
J Chen, JS Chen, S Li, F Zhang, J Deng… - Aging and …, 2024 - ncbi.nlm.nih.gov
Decades of research have demonstrated an incontrovertible role of amyloid-β (Aβ) in the
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …
etiology of Alzheimer's disease (AD). However, the overemphasis on the pathological …
[HTML][HTML] Can Genetic Markers Predict the Sporadic Form of Alzheimer's Disease? An Updated Review on Genetic Peripheral Markers
D Theron, LN Hopkins, HG Sutherland… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia that affects millions of
individuals worldwide. Although the research over the last decades has provided new …
individuals worldwide. Although the research over the last decades has provided new …
MDGA1 negatively regulates amyloid precursor protein–mediated synapse inhibition in the hippocampus
J Kim, S Kim, H Kim, IW Hwang, S Bae… - Proceedings of the …, 2022 - National Acad Sciences
Balanced synaptic inhibition, controlled by multiple synaptic adhesion proteins, is critical for
proper brain function. MDGA1 (meprin, A-5 protein, and receptor protein-tyrosine …
proper brain function. MDGA1 (meprin, A-5 protein, and receptor protein-tyrosine …
[HTML][HTML] SPIN90 Deficiency Ameliorates Amyloid β Accumulation by Regulating APP Trafficking in AD Model Mice
Y Oh, W Lee, SH Kim, S Lee, BC Kim, KH Lee… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD), a common form of dementia, is caused in part by the aggregation
and accumulation in the brain of amyloid β (Aβ), a product of the proteolytic cleavage of …
and accumulation in the brain of amyloid β (Aβ), a product of the proteolytic cleavage of …
[HTML][HTML] Genetic and Epigenetic Biomarkers Linking Alzheimer's Disease and Age-Related Macular Degeneration
Alzheimer's disease (AD) represents a prominent neurodegenerative disorder (NDD),
accounting for the majority of dementia cases worldwide. In addition to memory deficits …
accounting for the majority of dementia cases worldwide. In addition to memory deficits …
[PDF][PDF] Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction
The diagnosis, treatment, and management of dementia provide significant challenges due
to its chronic cognitive impairment. The complexity of this condition is further highlighted by …
to its chronic cognitive impairment. The complexity of this condition is further highlighted by …
[HTML][HTML] Alzheimer's Disease; Mechanism, Mutations, and Applications of Nano-Medicine
Background: In the past 10 years, significant progress has been made in understanding the
pathogenic chain of events that causes Alzheimer's disease (AD). According to the most …
pathogenic chain of events that causes Alzheimer's disease (AD). According to the most …