Microglia, the macrophages of the central nervous system parenchyma, have in the normal
healthy brain a distinct phenotype induced by molecules expressed on or secreted by …

Infection with the human immunodeficiency virus (HIV) results in a profound
immunosuppression due predominantly to a selective depletion of helper/inducer T …

We constructed an infectious molecular clone of acquired immunodeficiency syndrome-
associated retrovirus. Upon transfection, this clone directed the production of infectious virus …

One of the common neurological complications in patients with the acquired immune
deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By …

Cells with properties characteristic of mononuclear phagocytes were evaluated for infectivity
with five different isolates of the AIDS virus, HTLV-III/LAV. Mononuclear phagocytes cultured …

Monocytes were maintained in tissue culture for greater than 3 mo in media supplemented
with rCSF-1. These cultures provided susceptible target cells for isolation and propagation of …

To establish the phenotype of human T-cell leukemia virus type 1 (HTLV-1)-infected cells in
peripheral blood, the polymerase chain reaction was used to detect and quantitate viral DNA …

Normal blood-derived monocyte/macrophages were found to be susceptible to infection in
vitro by human T lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired …

The small ruminant lentiviruses include the prototype for the genus, visna-maedi virus (VMV)
as well as caprine arthritis encephalitis virus (CAEV). Infection of sheep or goats with these …

The structures of the molecular clones employed in this study are presented in Figure 1. The
plasmid pHXl32gpt contains a biologically active HTLV-III proviral clone inserted in the …