In the past decade substantial progress has been made in understanding the organization
and biological activity of amphotericin B (AmB) in the presence of sterols in lipid …

Langmuir monolayers at the air/water interface have been used for decades to mimic cell
membranes in attempts to determine the mechanisms behind the physiological action of …

Covering: 1985 up to the end of 2016 Fluorescence is a remarkable property of many
natural products in addition to their medicinal and biological values. Herein, we provide a …

The discovery that the lipids constituting the plasma membrane are not randomly distributed,
but instead are able to form laterally segregated lipid domains with different properties has …

Amphotericin B (AmB) is a lifesaving antibiotic used to treat deep-seated mycotic infections.
Both the pharmaceutical activity and highly toxic side effects of the drug rely on its interaction …

The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …

Amphotericin B (AmB) is a lifesaving polyene antibiotic used widely to treat deep-seated
mycoses. Both the pharmaceutical effectiveness as well as toxic side effects depend on …

Amphotericin B is an antimicrobial membrane-acting drug used in the treatment of systemic
fungal infections. However, the clinical utility of AmB is often low as a result of (i) dose …

Langmuir monolayers of amphotericin B (AmB) were investigated by recording π–A
isotherms under different pH conditions. To gain a better insight into antibiotic–membrane …

The molecular action of polyene macrolides with antifungal activity, amphotericin B and
natamycin, involves recognition of sterols in membranes. Physicochemical and functional …