The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …

Recent crystallographic studies have provided significant new insight into how receptor
tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor …

The number of N-glycans (n) is a distinct feature of each glycoprotein sequence and
cooperates with the physical properties of the Golgi N-glycan-branching pathway to regulate …

Conspectus Native mass spectrometry is nowadays widely used for determining the mass of
intact proteins and their noncovalent biomolecular assemblies. While this technology …

Protein glycosylation is an important posttranslational process, which regulates protein
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …

The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also
generates higher-order multimers, whose nature and function are poorly understood. We …

The epidermal growth factor receptor (EGFR) regulates several critical cellular processes
and is an important target for cancer therapy. In lieu of a crystallographic structure of the …

Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell
surface receptors, most of which are heavily glycosylated. This review discusses receptor …

Constitutive activation of receptor tyrosine kinases (RTKs) is a frequent event in human
cancer cells. Activating mutations in Fms-like tyrosine kinase 3 (FLT-3), notably, internal …