Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

Background Better understanding and prediction of progression of Parkinson's disease
could improve disease management and clinical trial design. We aimed to use longitudinal …

Background: Application of novel machine learning approaches to electronic health record
(EHR) data could provide valuable insights into disease processes. We utilized this …

Molecular networks governing responses to targeted therapies in cancer cells are complex
dynamic systems that demonstrate nonintuitive behaviors. We applied a novel …

Quantitative and systems pharmacology (QSP) is increasingly being applied in
pharmaceutical research and development. One factor critical to the ultimate success of QSP …

Molecular analysis of blood samples is pivotal to clinical diagnosis and has been intensively
investigated since the rise of systems biology. Recent developments have opened new …

Despite significant efforts and remarkable progress, the inference of signaling networks from
experimental data remains very challenging. The problem is particularly difficult when the …

Recent studies have demonstrated the utility of using systems approaches to identify
molecular signatures that can be used to predict vaccine immunity in humans. Such …