Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Androgen deprivation is the cornerstone of prostate cancer treatment. It results in involution
of the normal gland to~ 90% of its original size because of the loss of luminal cells. The …

The prostate gland consists of basal and luminal cells arranged as pseudostratified
epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate …

Objectives To present historical and contemporary hypotheses on the pathogenesis of
benign prostatic hyperplasia (BPH), and the potential implications for current medical …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Background At the surface of body organs, epithelial tissues must withstand harsh external
environments. To do so, they rely heavily upon stem cells to replenish and repair wounds …

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …

The intrinsic ability to exhibit self-organizing morphogenetic properties in ex vivo culture may
represent a general property of tissue stem cells. Here we show that single luminal …