Highlights•Apathy and impulsivity are common consequences of frontotemporal lobar
degeneration syndromes.•Common frontostriatal loops mediate different modes of apathy …

A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …

The catecholamine-containing brainstem nuclei locus coeruleus (LC) and ventral tegmental
area (VTA) are critically involved in stress responses. Alterations of catecholamine systems …

Objective To investigate the contribution of substantia nigra (SN) and locus coeruleus (LC)
pathology to clinical signs and symptoms in Parkinson disease (PD) by applying …

Cognitive fluctuations are a characteristic and distressing disturbance of attention and
consciousness seen in patients with Dementia with Lewy bodies and Parkinson's disease …

Neurodegeneration of the locus coeruleus (LC) in age-related neurodegenerative diseases
such as Alzheimer's disease (AD) is well documented. However, detailed studies of LC …

Background: The locus coeruleus (LC) is a nucleus in the human brainstem with a variety of
noradrenaline-driven functions involved in cognition, emotions, and perception. Dementia …

Introduction Given the challenges concerning the differential diagnosis of dementia, we
investigated the possible added value of monoaminergic compounds to the standard …

Background: Lewy body dementia (LBD) has two main phenotypes: Parkinson's disease
dementia (PDD) and dementia with Lewy bodies (DLB), separated by the 'one-year-rule' …

Dementia with Lewy bodies (DLB) is an insidious neurodegenerative disease characterised
by a precipitous decline in cognition, sleep disturbances, motor impairment and psychiatric …