Obesity is defined as abnormal and excessive fat accumulation, and it is a risk factor for
developing metabolic and neurodegenerative diseases and cognitive deficits. Obesity is …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to
dementia and patient death. AD is characterized by intracellular neurofibrillary tangles …

Background Obesity rates are increasing worldwide. Obesity leads to many complications,
including predisposing individuals to the development of cognitive impairment as they age …

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …

Obesity, prediabetes, and diabetes are growing in prevalence worldwide. These metabolic
disorders are associated with neurodegenerative diseases, particularly Alzheimer's disease …

Background The vast majority of women with dementia are post-menopausal. Despite
clinical relevance, menopause is underrepresented in rodent models of dementia. Before …

Background Damage to the cerebral vasculature can lead to vascular contributions to
cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to …

Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Background Higher mid-life body mass index (BMI) is associated with lower late-life
cognition. Associations between later-life BMI and cognition are less consistent; evidence …

Diabetes mellitus is a non-communicable metabolic disease hallmarked by chronic
hyperglycemia caused by beta-cell failure. Diabetic complications affect the vasculature and …