Vitamin C—sources, physiological role, kinetics, deficiency, use, toxicity, and determination

M Doseděl, E Jirkovský, K Macáková, LK Krčmová… - Nutrients, 2021 - mdpi.com
Vitamin C (L-ascorbic acid) has been known as an antioxidant for most people. However, its
physiological role is much larger and encompasses very different processes ranging from …

The pharmacokinetics of vitamin C

J Lykkesfeldt, P Tveden-Nyborg - Nutrients, 2019 - mdpi.com
The pharmacokinetics of vitamin C (vitC) is indeed complex. Regulated primarily by a family
of saturable sodium dependent vitC transporters (SVCTs), the absorption and elimination …

Targeting cancer vulnerabilities with high-dose vitamin C

B Ngo, JM Van Riper, LC Cantley, J Yun - Nature Reviews Cancer, 2019 - nature.com
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

AC Carr, PC Rosengrave, S Bayer, S Chambers… - Critical care, 2017 - Springer
Background Vitamin C is an essential water-soluble nutrient which cannot be synthesised or
stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive …

Vitamin C: the known and the unknown and Goldilocks

SJ Padayatty, M Levine - Oral diseases, 2016 - Wiley Online Library
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

Ascorbic acid: chemistry, biology and the treatment of cancer

J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

Factors affecting vitamin C status and prevalence of deficiency: A global health perspective

AC Carr, S Rowe - Nutrients, 2020 - mdpi.com
A recent review of global vitamin C status has indicated a high prevalence of deficiency,
particularly in low-and middle-income countries, as well as in specific subgroups within high …

Vitamin C and cardiovascular disease: an update

MB Morelli, J Gambardella, V Castellanos, V Trimarco… - Antioxidants, 2020 - mdpi.com
The potential beneficial effects of the antioxidant properties of vitamin C have been
investigated in a number of pathological conditions. In this review, we assess both clinical …

Dietary vitamin C in human health

M Granger, P Eck - Advances in food and nutrition research, 2018 - Elsevier
Vitamin C is essential to prevent scurvy in humans and is implicated in the primary
prevention of common and complex diseases such as coronary heart disease, stroke, and …

Does vitamin C influence neurodegenerative diseases and psychiatric disorders?

J Kocot, D Luchowska-Kocot, M Kiełczykowska, I Musik… - Nutrients, 2017 - mdpi.com
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit
C helps maintain integrity and function of several processes in the central nervous system …