The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Is there new hope for therapeutic matrix metalloproteinase inhibition?

RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in …

X Taylor, IM Clark, GJ Fitzgerald, H Oluoch… - Molecular …, 2023 - Springer
Background Amyloid-related imaging abnormalities (ARIA) have been identified as the most
common and serious adverse events resulting from pathological changes in the cerebral …

Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression

Y Gong, UD Chippada-Venkata, WK Oh - Cancers, 2014 - mdpi.com
Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in
the degradation of the extracellular matrix, play an important role in tissue remodeling …

Matrix metalloproteinases in kidney homeostasis and diseases

RJ Tan, Y Liu - American journal of physiology-renal …, 2012 - journals.physiology.org
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have
been increasingly linked to both normal physiology and abnormal pathology in the kidney …

[HTML][HTML] Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis

L Shan, F Wang, D Zhai, X Meng, J Liu, X Lv - Biomedicine & …, 2023 - Elsevier
Liver fibrosis is the common consequence of various chronic liver injuries and is mainly
characterized by the imbalance between the production and degradation of extracellular …

Matrix metalloproteinases and synovial joint pathology

CJ Malemud - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a
critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis …

Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis

RL Li, HX Duan, Q Liang, YL Huang, LY Wang… - Frontiers in …, 2022 - frontiersin.org
As a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into
collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous …

[HTML][HTML] Regulation of trophoblast invasion: the role of matrix metalloproteinases

JY Zhu, ZJ Pang, Y Yu - Reviews in obstetrics and gynecology, 2012 - ncbi.nlm.nih.gov
Pregnancy success is determined by a complex progress that includes trophoblast invasion
and placentation. Matrix metalloproteinases (MMPs) and tissue inhibitors of …