Cognitive impairment is commonly associated with the pain experience. This impairment
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Hemispheric asymmetries within the brain have been identified across taxa and have been
extensively studied since the early 19th century. Here, we discuss lateralization of a brain …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …

The amygdala is a structure of the temporal lobe thought to be involved in assigning
emotional significance to environmental information and triggering adapted physiological …

Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …

Objective This article reviews the structural and functional changes in pain chronification
and explores the association between memory and the development of chronic pain …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …