Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes

F Zatterale, M Longo, J Naderi, GA Raciti… - Frontiers in …, 2020 - frontiersin.org
Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Metabolic adaptation and maladaptation in adipose tissue

ET Chouchani, S Kajimura - Nature metabolism, 2019 - nature.com
Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Mitochondrial dysfunction in obesity

AH de Mello, AB Costa, JDG Engel, GT Rezin - Life sciences, 2018 - Elsevier
Obesity leads to various changes in the body. Among them, the existing inflammatory
process may lead to an increase in the production of reactive oxygen species (ROS) and …

Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity

HE Kunz, CR Hart, KJ Gries, M Parvizi… - American Journal …, 2021 - journals.physiology.org
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …

The influence of oxidative stress on thyroid diseases

J Kochman, K Jakubczyk, P Bargiel, K Janda-Milczarek - Antioxidants, 2021 - mdpi.com
Thyroid diseases, including neoplasms, autoimmune diseases and thyroid dysfunctions, are
becoming a serious social problem with rapidly increasing prevalence. The latter is …

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

P Gurung, JR Lukens, TD Kanneganti - Trends in molecular medicine, 2015 - cell.com
Recent studies have identified new roles for mitochondria in the regulation of
autoinflammatory processes. Emerging data suggests that the release of danger signals …

Impaired mitochondrial biogenesis in adipose tissue in acquired obesity

S Heinonen, J Buzkova, M Muniandy, R Kaksonen… - Diabetes, 2015 - Am Diabetes Assoc
Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …

Fat cell size: measurement methods, pathophysiological origins, and relationships with metabolic dysregulations

RZ Ye, G Richard, N Gévry, A Tchernof… - Endocrine …, 2022 - academic.oup.com
The obesity pandemic increasingly causes morbidity and mortality from type 2 diabetes,
cardiovascular diseases and many other chronic diseases. Fat cell size (FCS) predicts …

Mitochondria in white, brown, and beige adipocytes

M Cedikova, M Kripnerová, J Dvorakova… - Stem cells …, 2016 - Wiley Online Library
Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …