Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease
EV Mitroshina, MO Savyuk, E Ponimaskin… - Frontiers in cell and …, 2021 - frontiersin.org
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …
Determinants and biomarkers of progression independent of relapses in multiple sclerosis
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …
smoldering inflammatory activity is present from the earliest stages of the disease and …
[HTML][HTML] Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction
A Hadjihambi, C Konstantinou, J Klohs, K Monsorno… - Journal of …, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has been associated with
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …
Regulation of stress granule formation in human oligodendrocytes
F Pernin, QL Cui, A Mohammadnia… - Nature …, 2024 - nature.com
Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple
sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs …
sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs …
Significance of mitochondrial dysfunction in the progression of multiple sclerosis
AV Blagov, VN Sukhorukov, AN Orekhov… - International Journal of …, 2022 - mdpi.com
The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis
require further study of the factors underlying the progression of this disease. The prominent …
require further study of the factors underlying the progression of this disease. The prominent …
The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation
M Narine, MA Azmi, M Umali, A Volz… - Frontiers in Cellular …, 2023 - frontiersin.org
Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction
of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to …
of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to …
Sleep-disordered breathing and neurocognitive function in multiple sclerosis: Differential associations across cognitive domains
TR Valentine, AL Kratz, N Kaplish… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Sleep disorders are common in people with multiple sclerosis (PwMS) and
could contribute to cognitive dysfunction. However, effects of pathological sleep on cognitive …
could contribute to cognitive dysfunction. However, effects of pathological sleep on cognitive …
Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis
Studying the relationship between cerebral oxygen utilization and cognitive impairment is
essential to understanding neuronal functional changes in the disease progression of …
essential to understanding neuronal functional changes in the disease progression of …
The role of brain inflammation and abnormal brain oxygen homeostasis in the development of hepatic encephalopathy
ACD Mikkelsen, KL Thomsen, RP Mookerjee… - Metabolic Brain …, 2023 - Springer
Hepatic encephalopathy (HE) is a frequent complication of chronic liver disease (CLD) and
has a complex pathogenesis. Several preclinical and clinical studies have reported the …
has a complex pathogenesis. Several preclinical and clinical studies have reported the …
Temporal pattern of cortical hypoxia in Multiple Sclerosis and its significance on neuropsychological and clinical measures of disability
DD Adingupu, T Evans, A Soroush… - Annals of …, 2023 - Wiley Online Library
Objective Multiple sclerosis (MS) is a degenerative disease of the central nervous system
(CNS) characterized by inflammation, demyelination, and axonal damage. It has been …
(CNS) characterized by inflammation, demyelination, and axonal damage. It has been …