Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease

EV Mitroshina, MO Savyuk, E Ponimaskin… - Frontiers in cell and …, 2021 - frontiersin.org
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

Determinants and biomarkers of progression independent of relapses in multiple sclerosis

M Calabrese, P Preziosa, A Scalfari… - Annals of …, 2024 - Wiley Online Library
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …

[HTML][HTML] Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction

A Hadjihambi, C Konstantinou, J Klohs, K Monsorno… - Journal of …, 2023 - Elsevier
Background & Aims Non-alcoholic fatty liver disease (NAFLD) has been associated with
mild cerebral dysfunction and cognitive decline, although the exact pathophysiological …

Regulation of stress granule formation in human oligodendrocytes

F Pernin, QL Cui, A Mohammadnia… - Nature …, 2024 - nature.com
Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple
sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs …

Significance of mitochondrial dysfunction in the progression of multiple sclerosis

AV Blagov, VN Sukhorukov, AN Orekhov… - International Journal of …, 2022 - mdpi.com
The prevalence of multiple sclerosis and the complexity of its etiology and pathogenesis
require further study of the factors underlying the progression of this disease. The prominent …

The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

M Narine, MA Azmi, M Umali, A Volz… - Frontiers in Cellular …, 2023 - frontiersin.org
Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction
of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to …

Sleep-disordered breathing and neurocognitive function in multiple sclerosis: Differential associations across cognitive domains

TR Valentine, AL Kratz, N Kaplish… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Sleep disorders are common in people with multiple sclerosis (PwMS) and
could contribute to cognitive dysfunction. However, effects of pathological sleep on cognitive …

Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis

H Sawan, C Li, S Buch, E Bernitsas… - Journal of Cerebral …, 2024 - journals.sagepub.com
Studying the relationship between cerebral oxygen utilization and cognitive impairment is
essential to understanding neuronal functional changes in the disease progression of …

The role of brain inflammation and abnormal brain oxygen homeostasis in the development of hepatic encephalopathy

ACD Mikkelsen, KL Thomsen, RP Mookerjee… - Metabolic Brain …, 2023 - Springer
Hepatic encephalopathy (HE) is a frequent complication of chronic liver disease (CLD) and
has a complex pathogenesis. Several preclinical and clinical studies have reported the …

Temporal pattern of cortical hypoxia in Multiple Sclerosis and its significance on neuropsychological and clinical measures of disability

DD Adingupu, T Evans, A Soroush… - Annals of …, 2023 - Wiley Online Library
Objective Multiple sclerosis (MS) is a degenerative disease of the central nervous system
(CNS) characterized by inflammation, demyelination, and axonal damage. It has been …