Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

Despite the emergence of mitochondria as key regulators of innate immunity, the
mechanisms underlying the generation and release of immunostimulatory alarmins by …

Nanomedicine‐based synergy of chemodynamic therapy (CDT) and radiotherapy (RT)
modulated by tumor microenvironment enables rapid tumor ablation, which holds great …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

Incidence of early-onset colorectal cancer (EOCRC), defined by a diagnosed age under 50
years, is increasing, but its heterogeneous etiologies that differ from general CRC remain …

Background Age-related changes in immune cell composition and functionality are
associated with multimorbidity and mortality. However, many centenarians delay the onset of …

Immunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to
promote an adaptive immune response against antigens of the dying cell in an …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …