Isoprenylation is a posttranslational modification that involves the formation of thioether
bonds between cysteine and isoprenyl groups derived from pyrophosphate intermediates of …

The regulation, functional activation, and intracellular targeting of biological macromolecules
are often mediated through the covalent attachment of specific chemical moieties. The …

The C-terminal CAAX motif of the yeast mating factors is modified by proteolysis to remove
the three terminal amino acids (-AAX) leaving a C-terminal cysteine resi-, due that is …

The a mating type locus of the phytopathogenic fungus U. maydis controls fusion of haploid
cells and filamentous growth of the dikaryotic mycelium. The a locus exists in two alleles …

The nuclear lamina proteins, prelamin A, lamin B, and a 70-kD lamina-associated protein,
are posttranslationally modified by a metabolite derived from mevalonate. This modification …

We have devised a screen for genes from the yeast Saccharomyces cerevisiae whose
expression is affected by cell type or by the mating pheromones. From this screen we …

Cnidarians are the lowest animal group having a nervous system and it was probably within
this phylum or in a related ancestor group that nervous systems first evolved. The primitive …

The mating pheromone a-factor secreted by Saccharomyces cerevisiae is a farnesylated
and carboxylmethylated peptide and is unusually hydrophobic compared to other …

During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell
stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval …

The peptide pheromone, a-factor, was found to elicit down regulation of receptor sites on
yeast a cell targets. Cellular uptake of a-factor accompanied the loss of receptor sites …