Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Scientific revolution [1] implies a transformation of the world view in which a dominant
paradigm is substituted by a new one, one which furnishes an ameliorated comprehension …

The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of
serious hepatotoxicity, typically with a delayed onset (> 1–3 months). Because there is no …

An electrochemical sensor developed for analysis of diclofenac by modification of carbon
paste electrodes using NiO-SWCNTs as conductive mediator and 2, 4-dimethyl-N/-[1-(2, 3 …

Different tissues display distinct sensitivities to defective mitochondrial oxidative
phosphorylation (OXPHOS). Tissues highly dependent on oxygen such as the cardiac …

Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with idiosyncratic
hepatotoxicity in susceptible patients. The molecular mechanisms underlying this toxicity …

Diclofenac (DCLF) is a nonsteroidal anti-inflammatory drug that is widely used for the
treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …