Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

The skin microbiome: current landscape and future opportunities

P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Emerging nanotechnologies for targeting antimicrobial resistance

PJ Weldick, A Wang, AF Halbus, VN Paunov - Nanoscale, 2022 - pubs.rsc.org
Antimicrobial resistance is a leading cause of mortality worldwide. Without newly approved
antibiotics and antifungals being brought to the market, resistance is being developed to the …

Enhanced clearing of wound-related pathogenic bacterial biofilms using protease-functionalized antibiotic nanocarriers

PJ Weldrick, MJ Hardman… - ACS applied materials & …, 2019 - ACS Publications
Biofilms are prevalent in chronic wounds and once formed are very hard to remove, which is
associated with poor outcomes and high mortality rates. Biofilms are comprised of surface …

Development of an experimental ex vivo wound model to evaluate antimicrobial efficacy of topical formulations

MÅ Andersson, LB Madsen, A Schmidtchen… - International journal of …, 2021 - mdpi.com
Wound infections are considered a major cause for wound-associated morbidity. There is a
high demand for alternative, robust, and affordable methods that can provide relatable and …

Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures

M Ashrafi, L Novak-Frazer, M Bates, M Baguneid… - Scientific Reports, 2018 - nature.com
Biofilms are major contributors to delayed wound healing and there is a need for clinically
relevant experimental models to assess theranostics. Microorganisms release volatile …

Wound senescence: A functional link between diabetes and ageing?

HN Wilkinson, MJ Hardman - Experimental Dermatology, 2021 - Wiley Online Library
Arguably, the two most important causes of pathological healing in the skin are diabetes and
ageing. While these factors have historically been considered independent modifiers of the …

A Novel Silver Bioactive Glass Elicits Antimicrobial Efficacy Against Pseudomonas aeruginosa and Staphylococcus aureus in an ex Vivo Skin Wound Biofilm Model

HN Wilkinson, S Iveson, P Catherall… - Frontiers in …, 2018 - frontiersin.org
Biofilm infection is now understood to be a potent contributor to the recalcitrant nature of
chronic wounds. Bacterial biofilms evade the host immune response and show increased …

Antibiofilm activity of chitosan/epsilon‐poly‐L‐lysine hydrogels in a porcine ex vivo skin wound polymicrobial biofilm model

BA Pati, WE Kurata, TS Horseman… - Wound Repair and …, 2021 - Wiley Online Library
As antibiotic resistance continues to increase globally, there is an urgency for novel, non‐
antibiotic approaches to control chronic drug‐resistant infections, particularly those …

Development of In Vitro and Ex Vivo Biofilm Models for the Assessment of Antibacterial Fibrous Electrospun Wound Dressings

K Lorenz, L Preem, K Sagor, M Putrins… - Molecular …, 2023 - ACS Publications
Increasing evidence suggests that the chronicity of wounds is associated with the presence
of bacterial biofilms. Therefore, novel wound care products are being developed, which can …