Protein export through the bacterial Sec pathway
A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …
export machinery for most proteins that integrate into, or translocate through, the plasma …
Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …
The treatment options against infections caused by multiple drug-resistant bacteria are …
X-ray structure of a protein-conducting channel
A conserved heterotrimeric membrane protein complex, the Sec61 or SecY complex, forms a
protein-conducting channel, allowing polypeptides to be transferred across or integrated into …
protein-conducting channel, allowing polypeptides to be transferred across or integrated into …
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
TA Rapoport - Nature, 2007 - nature.com
A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
[HTML][HTML] Sec-and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
Protein translocation across the bacterial cytoplasmic membrane
AJM Driessen, N Nouwen - Annu. Rev. Biochem., 2008 - annualreviews.org
About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …
Recombinant protein secretion in Escherichia coli
FJM Mergulhão, DK Summers, GA Monteiro - Biotechnology advances, 2005 - Elsevier
The secretory production of recombinant proteins by the Gram-negative bacterium
Escherichia coli has several advantages over intracellular production as inclusion bodies. In …
Escherichia coli has several advantages over intracellular production as inclusion bodies. In …
[HTML][HTML] Structure of a complex of the ATPase SecA and the protein-translocation channel
Most proteins are secreted from bacteria by the interaction of the cytoplasmic SecA ATPase
with a membrane channel, formed by the heterotrimeric SecY complex. Here we report the …
with a membrane channel, formed by the heterotrimeric SecY complex. Here we report the …
Cryo-EM structure of the ribosome–SecYE complex in the membrane environment
Abstract The ubiquitous SecY–Sec61 complex translocates nascent secretory proteins
across cellular membranes and integrates membrane proteins into lipid bilayers. Several …
across cellular membranes and integrates membrane proteins into lipid bilayers. Several …