The evolution of the eye is a matter of debate ever since Darwin's Origin of Species. While
morphological comparisons of eye anatomy and photoreceptor cell types led to the view that …

This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …

Immune molecules, including complement proteins C1q and C3, have emerged as critical
mediators of synaptic refinement and plasticity. Complement localizes to synapses and …

GABAergic dysfunction is present in the hippocampus in schizophrenia (SZ) and bipolar
disorder (BD). The trisynaptic pathway was “deconstructed” into various layers of sectors …

ABSTRACT Müller glial cells are the major type of glia in the mammalian retina. To identify
the molecular machinery that defines Müller glial cell identity and function, single cell gene …

Visual information is conveyed to the brain by axons of> 30 retinal ganglion cell (RGC)
types. Characterization of these types is a prerequisite to understanding visual perception …

Retinitis pigmentosa (RP), a family of inherited disorders characterized by progressive
photoreceptor death, is a leading cause of blindness with no available cure. Despite the …

In the mammalian pineal gland, information on environmental lighting conditions that is
neuronally encoded by the retina is converted into nocturnally elevated synthesis of the …

Photoreceptors, rods and cones are the most abundant cell type in the mammalian retina.
However, the molecules that control their development are not fully understood. In studies of …

It is widely accepted that the process of retinal cell fate determination is under tight
transcriptional control mediated by a combinatorial code of transcription factors. However …