The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer
drugs. With small size (10–100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit …

PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and
maintains chromosomal integrity in the nucleus. Nucleus–cytoplasm shuttling of PTEN is …

CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that
restore the normal apoptotic pathways have the potential for effectively treating cancers that …

Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …

Defects in apoptosis regulation are one main cause of cancer development and may result
from overexpression of anti-apoptotic proteins such as inhibitor of apoptosis proteins (IAPs) …

Inflammation, although first characterized by Cornelius Celsus, a physician in first Century
Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a …

The X-linked inhibitor of apoptosis protein (XIAP) is a potent cellular inhibitor of apoptosis.
Designing small-molecule inhibitors that target the BIR3 domain of XIAP, where …