[HTML][HTML] Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum

S Li, X Cheng, C Wang - Journal of Ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance The plants of the genus Peganum have a long history as a
Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma …

[HTML][HTML] Analogous β-carboline alkaloids harmaline and harmine ameliorate scopolamine-induced cognition dysfunction by attenuating acetylcholinesterase activity …

SP Li, YW Wang, SL Qi, YP Zhang, G Deng… - Frontiers in …, 2018 - frontiersin.org
The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a
variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity …

Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells

C Li, Y Wang, C Wang, X Yi, M Li, X He - Phytomedicine, 2017 - Elsevier
Background Harmine, a β-carboline alkaloid from Peganum harmala, has multiple anti-
tumor activities, especially for its folk therapy for digestive system neoplasm. However, the …

[HTML][HTML] Optimization of PhysicoChemical Parameters for Production of Cytotoxic Secondary Metabolites and Apoptosis Induction Activities in the Culture Extract of a …

S Taritla, M Kumari, S Kamat, SG Bhat… - Frontiers in …, 2021 - frontiersin.org
The endophytic fungal community in the marine ecosystem has been demonstrated to be
relevant source of novel and pharmacologically active secondary metabolites. The current …

[HTML][HTML] Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts

TA Diab, T Donia, KM Saad-Allah - Beni-Suef University Journal of Basic …, 2021 - Springer
Background Natural products from plants are very safe as compared to synthetic ones, so
the aim of this study was to assess the in vitro antioxidant and antitumor activities of the …

Peganum spp.: A Comprehensive Review on Bioactivities and Health‐Enhancing Effects and Their Potential for the Formulation of Functional Foods and …

J Sharifi-Rad, C Quispe, J Herrera-Bravo… - Oxidative Medicine …, 2021 - Wiley Online Library
The genus Peganum includes four species widely distributed in warm temperate to
subtropical regions from the Mediterranean to Mongolia as well as certain regions in …

Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L.(European black nightshade)

L Xiang, Y Wang, X Yi, X He - Phytochemistry, 2018 - Elsevier
Seven previously undescribed steroidal glycosides, along with three known congeners were
isolated from the unripe berries of Solanum nigru m L.(Solanaceae). Their structures were …

Cytotoxic quinazoline alkaloids from the seeds of Peganum harmala

SG Li, KB Wang, C Gong, Y Bao, NB Qin, DH Li… - Bioorganic & medicinal …, 2018 - Elsevier
Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers,
named as (S)-and (R)-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β-d-glucopyranosyl …

Anti-tumor alkaloids from Peganum harmala

Q Zhang, YH Zan, HG Yang, MY Yang, FS Liu, SG Li… - Phytochemistry, 2022 - Elsevier
Six alkaloids peharmalines F–K, along with 14 known ones, were isolated from the aerial
part of Peganum harmala L.. The structures of the isolated compounds were determined …