Ventromedial hypothalamic neurons control a defensive emotion state
PS Kunwar, M Zelikowsky, R Remedios, H Cai… - Elife, 2015 - elifesciences.org
Defensive behaviors reflect underlying emotion states, such as fear. The hypothalamus
plays a role in such behaviors, but prevailing textbook views depict it as an effector of …
plays a role in such behaviors, but prevailing textbook views depict it as an effector of …
Critical neuropsychobiological analysis of panic attack-and anticipatory anxiety-like behaviors in rodents confronted with snakes in polygonal arenas and complex …
NC Coimbra, T Paschoalin-Maurin, GS Bassi… - Revista Brasileira de …, 2017 - SciELO Brasil
Objective: To compare prey and snake paradigms performed in complex environments to
the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack-and …
the elevated plus-maze (EPM) and T-maze (ETM) tests for the study of panic attack-and …
Dopamine release and negative valence gated by inhibitory neurons in the laterodorsal tegmental nucleus
Y Du, S Zhou, C Ma, H Chen, A Du, G Deng, Y Liu… - Neuron, 2023 - cell.com
GABAergic neurons in the laterodorsal tegmental nucleus (LDT GABA) encode aversion by
directly inhibiting mesolimbic dopamine (DA). Yet, the detailed cellular and circuit …
directly inhibiting mesolimbic dopamine (DA). Yet, the detailed cellular and circuit …
Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus
A Pérez-Gómez, K Bleymehl, B Stein, M Pyrski… - Current Biology, 2015 - cell.com
The existence of innate predator aversion evoked by predator-derived chemostimuli called
kairomones offers a strong selective advantage for potential prey animals. However, it is …
kairomones offers a strong selective advantage for potential prey animals. However, it is …
CB1 receptor signalling mediates cannabidiol-induced panicolytic-like effects and defensive antinociception impairment in mice threatened by Bothrops jararaca …
BM de Paula Rodrigues… - Journal of …, 2022 - journals.sagepub.com
Background: Cannabis sativa-derived substances such as cannabidiol (CBD) have attracted
increasing clinical interest and consist in a new perspective for treating some neurological …
increasing clinical interest and consist in a new perspective for treating some neurological …
Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates …
A Uribe-Marino, A Francisco… - …, 2012 - nature.com
Several pharmacological targets have been proposed as modulators of panic-like reactions.
However, interest should be given to other potential therapeutic neurochemical agents …
However, interest should be given to other potential therapeutic neurochemical agents …
Identification of a novel perifornical-hypothalamic-area-projecting serotonergic system that inhibits innate panic and conditioned fear responses
CS Bernabe, IF Caliman, ARR de Abreu… - Translational …, 2024 - nature.com
Abstract The serotonin (5-HT) system is heavily implicated in the regulation of anxiety and
trauma-related disorders such as panic disorder and post-traumatic stress disorder …
trauma-related disorders such as panic disorder and post-traumatic stress disorder …
An adapted chronic constriction injury of the sciatic nerve produces sensory, affective, and cognitive impairments: a peripheral mononeuropathy model for the study of …
P Medeiros, IR Dos Santos, IM Júnior, E Palazzo… - Pain …, 2021 - academic.oup.com
Background Chronic constriction injury (CCI) is a model of neuropathic pain induced by four
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
Steroidogenic factor 1 and the central nervous system
Steroidogenic factor 1 (SF‐1; officially designated NR5a1) is a member of a nuclear receptor
superfamily with important roles in the development of endocrine systems. Studies with …
superfamily with important roles in the development of endocrine systems. Studies with …
Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of …
F Ullah, T dos Anjos-Garcia, IR dos Santos… - Behavioural Brain …, 2015 - Elsevier
Electrical stimulation of the periaqueductal gray matter and ventromedial hypothalamus in
humans showed the involvement of both these structures in panic attacks. The aim of this …
humans showed the involvement of both these structures in panic attacks. The aim of this …