Loss of skeletal muscle mass is a primary feature of sarcopenia and cancer cachexia. In
cancer patients, tumor-derived inflammatory factors promote muscle atrophy via tumor-to …

Introduction Epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
and mutated in multiple cancers. In normal cell physiology, EGFR signaling controls cellular …

Helicobacter pylori (H. pylori) infection is the primary risk factor for the progress of gastric
diseases. The persistent stomach colonization of H. pylori is closely associated with the …

Asporin (ASPN) has been identified as one of the members of the class I small leucine-rich
proteoglycans (SLRPs) family in the extracellular matrix (ECM). It is involved in classic …

Objective: Endometriosis is a benign gynecological disease characterized by distant
metastasis. Previous studies have discovered abnormal numbers and function of immune …

Simple Summary Proteoglycans are important structural and functional components of
extracellular matrices that govern phenotype and functions of resident cells. They are often …

Abstract Acute Kidney Injury (AKI) is a multifaceted condition characterised by rapid
deterioration of renal function, often precipitated by diverse etiologies. A comprehensive …

Gastric cancer (GC) has high rates of morbidity and mortality, and this phenomenon is
particularly evident in coastal regions where local dietary habits favor the consumption of …

Solid tumors present a formidable challenge in oncology, necessitating innovative
approaches to improve therapeutic outcomes. Proteoglycans, multifaceted molecules within …

Abstract Mesothelin (MSLN), a tumor-associated antigen, is upregulated in various
malignancies, including gastric cancer (GC). In addition, MSLN is found in the blood-stream …